m-PEG12 NHS Ester
m-PEG12 NHS Ester is a high-purity, methoxy-capped PEG reagent featuring an N-hydroxysuccinimide (NHS) ester for rapid and efficient amine coupling. The PEG12 spacer specifically provides extended hydrophilicity, improved solubility, and greater flexibility compared to shorter PEG linkers, making it ideal for PEGylation of proteins, peptides, antibodies, and other amine-containing molecules. Its longer spacer length reduces steric hindrance and especially enhances accessibility to reactive sites in complex biomolecules.
Key Features and Benefits:
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NHS Ester Reactivity: Forms stable amide bonds with primary amines under mild, aqueous or organic conditions.
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PEG12 Spacer: Provides extended length for improved solubility, reduced steric hindrance, and enhanced conjugation efficiency.
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Methoxy-Capped Terminus: Ensures monofunctionality and prevents unwanted side reactions.
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High Purity: Supplied at >95% purity for consistent, reproducible results.
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Biocompatible: PEGylation reduces immunogenicity and increases in vivo circulation time.
Applications:
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Protein and Peptide PEGylation: Improve solubility, stability, and pharmacokinetics of therapeutic biomolecules.
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Antibody Modification: Conjugate PEG chains to antibodies for enhanced therapeutic performance.
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Surface Functionalization: Modify nanoparticles, biosensors, or devices to reduce nonspecific binding.
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Drug Delivery Systems: Extend the half-life and improve targeting of therapeutic agents.
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Diagnostic Probe Development: PEGylate imaging agents for better in vivo performance.
Storage and Handling:
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Storage: Store at -20°C, protected from light and moisture.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid exposure to moisture to prevent NHS hydrolysis.
m-PEG12 NHS Ester offers an especially extended PEG spacer for superior solubility and reduced steric hindrance, making it a top choice for applications requiring high-efficiency PEGylation and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
