Ald-CH2-PEG2-t-butyl ester
This high-purity PEG reagent has a reactive aldehyde for oxime or hydrazone ligation with aminooxy or hydrazide groups and a tert-butyl–protected carboxyl for mild acidic deprotection. The PEG2 spacer enhances solubility, flexibility, and reduces steric hindrance for especially efficient conjugation in aqueous and organic systems.
Features and Benefits
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Aldehyde Group – Reacts selectively with aminooxy and hydrazide groups to form stable oxime or hydrazone bonds.
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t-Butyl Ester Protection – Acid-labile protection for the carboxyl group, allowing orthogonal functionalization strategies.
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PEG2 Spacer – Enhances solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Supports stepwise conjugation of aldehyde and carboxyl functionalities.
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High Purity – Supplied at >95% purity for reproducible results in sensitive bioconjugation workflows.
Applications
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Protein, peptide, and carbohydrate labeling via oxime or hydrazone ligation
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Preparation of multifunctional bioconjugates
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Drug delivery systems requiring orthogonal protection strategies
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Nanoparticle and surface modification
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve aldehyde reactivity
This product offers an aldehyde group for oxime/hydrazone ligation and a t-butyl–protected carboxyl group for orthogonal functionalization, with a PEG2 spacer for solubility and flexibility, making it especially ideal for sequential bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
