Aminooxyacetamide-PEG3-propargyl
This high-purity heterobifunctional PEG linker features an aminooxyacetamide group for chemoselective oxime ligation with aldehydes or ketones, and a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The PEG3 spacer enhances solubility, flexibility, and reduces steric hindrance, specifically enabling efficient and orthogonal bioconjugation in both aqueous and organic systems.
Key Features and Benefits
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Aminooxyacetamide Group – Forms stable oxime bonds with aldehyde or ketone groups under mild conditions.
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Terminal Alkyne – Enables CuAAC click chemistry with azides for site-specific conjugation.
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PEG3 Spacer – Improves solubility and accessibility while minimizing steric interference.
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Orthogonal Reactivity – Supports sequential, chemoselective modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible, high-yield results.
Applications
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Orthogonal conjugation of biomolecules
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Protein, peptide, and antibody modification
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Multifunctional probe synthesis
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Targeted drug delivery systems
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product combines aldehyde/ketone oxime ligation with alkyne–azide click chemistry, linked by PEG3 for solubility and flexibility, ideal for orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
