endo-BCN-PNP carbonate

endo-BCN-PNP carbonate

This product is a heterobifunctional reagent featuring an endo-bicyclononyne (BCN) group for rapid, copper-free SPAAC ligation and a reactive PNP carbonate for amine coupling. This design specifically enables bioorthogonal labeling and multifunctional conjugation with enhanced solubility and controlled reactivity.

Key Features and Benefits:

• Endo-BCN Group: Supports ultrafast, catalyst-free SPAAC click chemistry with azides.

• PNP Carbonate: Efficiently couples with primary and secondary amines.

• Bioorthogonal Design: Ensures high selectivity under physiological conditions.

• Compact Structure: Reduces steric hindrance while maintaining reactivity.

• High Purity: Provides reproducibility in advanced conjugation workflows.

Applications:

• Bioorthogonal Labeling: Enables copper-free conjugation with azide-modified biomolecules.

• Bioconjugation: Links amines to BCN groups in multifunctional constructs.

• Probe Development: Builds stable, click-ready probes for imaging and diagnostics.

• Drug Delivery: Supports targeted conjugation strategies with high efficiency.

Storage and Handling:

• Storage: Store at –20 °C in a sealed, light-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to moisture.

This product integrates rapid SPAAC click chemistry with efficient amine coupling, making it an especially powerful tool for bioorthogonal conjugation, probe design, and targeted therapeutic development.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.