Fmoc-PEG4-alcohol
Fmoc-PEG4-alcohol is a high-purity heterobifunctional PEG linker featuring an Fmoc-protected amine on one end and a hydroxyl group on the other. The PEG4 spacer enhances aqueous solubility, increases flexibility, and reduces steric hindrance, making it ideal for stepwise conjugation and linker design in both aqueous and organic systems. The Fmoc group enables controlled deprotection for orthogonal functionalization, while the hydroxyl group serves as a versatile handle for further chemical modification.
Key Features and Benefits
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Fmoc-Protected Amine: Allows orthogonal, controlled deprotection for sequential conjugation strategies.
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Hydroxyl Group: Serves as a reactive site for etherification, esterification, or other coupling reactions.
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PEG4 Spacer: Improves solubility, flexibility, and accessibility of functional groups.
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Heterobifunctional Design: Supports multi-step synthesis for complex bioconjugates.
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High Purity: Supplied at >95% purity for consistent and reproducible performance.
Applications
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Stepwise Bioconjugation: Sequentially couple functional groups for precise molecular assembly.
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Peptide and Protein Modification: Introduce PEG linkers with dual reactive capabilities.
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Nanoparticle Functionalization: Provide hydrophilic linkers for surface modification.
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Drug Delivery Systems: Build modular linkers for targeted payload attachment.
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Material Science: Functionalize polymers and surfaces for advanced applications.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity.
Fmoc-PEG4-alcohol offers orthogonal reactivity with especially excellent solubility and flexibility, making it a versatile tool for multifunctional bioconjugates, precision linkers, and targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
