endo-BCN-PEG6-t-butyl ester
This product is a protected PEG linker featuring an endo-bicyclononyne (endo-BCN) group, a six-unit PEG spacer, and a t-butyl ester terminus. The endo-BCN enables strain-promoted azide–alkyne cycloaddition (SPAAC) for copper-free click chemistry, while the PEG6 chain enhances solubility and reduces steric hindrance. The t-butyl ester specifically protects the carboxylic acid until selective deprotection, offering controlled conjugation options.
Key Features and Benefits
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Endo-BCN Group: Enables ultrafast, copper-free click chemistry with azides via SPAAC.
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PEG6 Spacer: Improves solubility, flexibility, and accessibility during bioconjugation.
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t-Butyl Ester Protection: Stabilizes the carboxyl group until mild acidic deprotection is performed.
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Compact & Versatile: Provides balance between chain length and reactivity for efficient conjugation.
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High Purity: Manufactured to ≥95% purity for reliable and reproducible performance.
Applications
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Bioconjugation: Couples azide-functionalized biomolecules or probes through copper-free click chemistry.
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Probe Development: Serves as a protected intermediate for functional imaging or diagnostic probes.
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Drug Delivery: Integrates into cleavable linkers or PEGylated therapeutic systems.
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Organic Synthesis: Useful as a building block for multifunctional PEG linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, dry container, protected from light and moisture.
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Handling: Avoid repeated freeze–thaw cycles; deprotect t-butyl ester under mild acidic conditions when needed.
This product combines the bioorthogonal reactivity of BCN with PEG solubility and a protected acid terminus, making it an especially versatile intermediate for synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
