endo-BCN-PEG12-NHS ester
This product is a heterobifunctional linker containing an endo-bicyclononyne (BCN) group for copper-free SPAAC click chemistry and an NHS ester for efficient amine coupling. The PEG12 spacer provides long-chain solubility, flexibility, and steric spacing, making it especially effective for bioorthogonal labeling, probe development, and ADC design.
Key Features and Benefits:
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Endo-BCN Group: Reacts rapidly with azides via copper-free click chemistry.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG12 Spacer: Improves solubility, hydrophilicity, and reduced steric hindrance.
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Dual Reactivity: Combines bioorthogonal and amine-targeting chemistry.
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High Purity: Ensures reliable and reproducible results in advanced workflows.
Applications:
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Bioorthogonal Labeling: Supports rapid copper-free conjugation in vitro and in vivo.
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ADC Development: Provides long-chain PEG spacing for antibody–drug conjugates.
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Probe Development: Builds BCN-modified probes for imaging and diagnostics.
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Drug Delivery: Enhances solubility and circulation of therapeutic conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of the NHS ester.
This product combines rapid SPAAC click reactivity with amine coupling in a PEG12 scaffold, making it an especially versatile linker for conjugation, drug delivery, and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
