endo-BCN-PEG8-NHS ester
This product is a heterobifunctional linker featuring an endo-bicyclononyne (BCN) group for copper-free SPAAC click chemistry and an NHS ester for rapid amine coupling. The PEG8 spacer provides solubility, flexibility, and extended spacing, making it especially effective for bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
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Endo-BCN Group: Enables catalyst-free SPAAC click reactions with azides.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG8 Spacer: Enhances solubility, hydrophilicity, and steric accessibility.
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Dual Reactivity: Combines bioorthogonal click chemistry with amine coupling.
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High Purity: Ensures reproducibility in advanced applications.
Applications:
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Bioconjugation: Links biomolecules through orthogonal reactivity.
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Probe Development: Builds BCN-functionalized probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated linkers for stable therapeutic conjugates.
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Material Science: Functionalizes polymers, nanoparticles, and surfaces.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product combines bioorthogonal BCN reactivity with amine coupling in a PEG8 scaffold, specifically offering versatility for conjugation and advanced drug delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
