endo-BCN-PEG3-NHS ester
This product is a heterobifunctional linker featuring an endo-bicyclononyne (BCN) group for copper-free SPAAC click chemistry and an NHS ester for rapid amine conjugation. The PEG3 spacer provides solubility, flexibility, and compact spacing, making it especially ideal for probe development, bioconjugation, and drug delivery.
Key Features and Benefits:
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Endo-BCN Group: Enables catalyst-free SPAAC click reactions with azides.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG3 Spacer: Enhances hydrophilicity and steric accessibility.
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Dual Reactivity: Combines bioorthogonal and amine-targeted chemistry.
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High Purity: Ensures reproducible and reliable performance.
Applications:
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Bioconjugation: Links biomolecules via orthogonal chemistries.
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Probe Development: Builds BCN-functionalized probes for imaging and diagnostics.
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Drug Delivery: Supports stable PEGylated scaffolds for therapeutic systems.
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Material Science: Functionalizes surfaces, nanoparticles, and advanced polymers.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product integrates rapid SPAAC chemistry with amine coupling in a PEG3 scaffold, specifically offering solubility and orthogonal reactivity for multifunctional bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
