Ald-Ph-PEG2-t-butyl ester
This product is a heterobifunctional PEG2 linker featuring an aldehyde-functionalized phenyl group and a tert-butyl–protected ester. The PEG2 spacer imparts hydrophilicity and flexibility, while the aldehyde enables selective coupling with amines or hydrazides, and the tBu ester provides acid-labile protection for orthogonal conjugation strategies.
Key Features and Benefits:
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Aldehyde Group: Forms Schiff bases or hydrazones with amines and hydrazides.
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Phenyl Moiety: Adds rigidity and aromatic character for stable conjugates.
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tBu-Protected Ester: Acid-labile protection for controlled carboxyl release.
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PEG2 Spacer: Provides hydrophilicity and reduced steric hindrance.
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High Purity: Ensures reliable results in sensitive bioconjugation workflows.
Applications:
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Bioconjugation: Enables aldehyde–amine/hydrazide coupling with orthogonal protection.
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Drug Delivery: Facilitates linker–payload assembly with controlled deprotection.
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Surface Modification: Functionalizes polymers, nanoparticles, and biomaterials.
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Synthetic Chemistry: Versatile intermediate for orthogonal, stepwise conjugation.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected environment.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO, acetonitrile) to maintain aldehyde and ester stability.
This product ester provides aldehyde reactivity and orthogonal tBu protection in a compact PEG linker, making it an especially valuable tool for bioconjugation, drug delivery, and advanced synthetic chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
