1,1,1-Trifluoroethyl-PEG4-amine
This product is a heterobifunctional linker with a trifluoroethyl group, a PEG4 spacer, and a primary amine. The amine specifically reacts with carboxyls, NHS esters, or other electrophiles to form stable amide or urea bonds. The trifluoroethyl group adds hydrophobicity and fluorine tagging capability and the PEG4 chain specifically improves solubility and flexibility, supporting probe development and medicinal chemistry.
Key Features and Benefits
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Trifluoroethyl Group: Provides hydrophobicity and fluorine labeling potential.
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Amine Group: Couples efficiently with carboxyls or NHS esters.
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PEG4 Spacer: Improves solubility and reduces steric hindrance.
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Dual Functionality: Combines fluorine tagging with amine reactivity.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Medicinal Chemistry: Builds fluorinated PEGylated intermediates for drug discovery.
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Probe Development: Incorporates fluorine tags for NMR or MS detection.
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Bioconjugation: Couples biomolecules via amine-reactive chemistry.
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Material Science: Modifies polymers with PEGylated fluorinated groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use under dry conditions; prepare fresh solutions.
This product integrates a fluorine-rich moiety with PEG solubility and an amine handle, specifically providing a compact and versatile reagent for conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
