Azido-PEG2-amine (CAS 166388-57-4) is a versatile bifunctional linker with azide (N₃) and amine (NH₂) groups, connected by a two-unit PEG spacer. It is widely used in chemical biology and drug development for its flexibility in conjugation strategies.
Key Features:
- Molecular Formula: C₆H₁₄N₄O₂
- Molecular Weight: 174.20 g/mol
- Functional Groups: Azide (N₃) and primary amine (NH₂)
- Solubility: Highly soluble in water and organic solvents
Applications:
- Click Chemistry:
- The azide reacts with alkynes or strained cyclic systems, such as BCN, and DBCO linker to form stable triazoles via copper-catalyzed or strain-promoted cycloaddition.
- Bioconjugation:
- The amine reacts with carboxylic acids or NHS esters to attach biomolecules through amide bonds.
- PROTAC Development:
- Used as a linker in creating proteolysis-targeting chimeras for targeted protein degradation.
- Antibody-Drug Conjugates (ADCs):
- Enhances solubility and pharmacokinetics when used as a non-cleavable PEG linker.
Azido-PEG2-amine is a valuable tool for advancing research in molecular conjugation and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
