L- Homopropargylglycine (HPG) HCl salt

L-Homopropargylglycine (HPG) HCl salt

This product is a non-canonical amino acid featuring a terminal alkyne side chain and provided as a stable hydrochloride salt. The alkyne enables bioorthogonal click chemistry with azides, making HPG a useful methionine surrogate in protein labeling. Its specifically incorporation into proteins allows selective functionalization for bioconjugation, probe development, and imaging applications.

Key Features and Benefits

• Terminal Alkyne Group: Supports CuAAC and SPAAC click reactions with azides.

• Methionine Surrogate: Incorporates into proteins in place of methionine during expression.

• Hydrochloride Salt Form: Improves stability and handling.

• Bioorthogonal Reactivity: Enables selective labeling in living cells.

• High Purity: Produced to ≥95% purity for reproducible results.

Applications

• Protein Labeling: Incorporates into proteins for site-specific functionalization.

• Bioconjugation: Couples proteins or peptides with azide-tagged probes and biomolecules.

• Probe Development: Builds alkyne-functionalized probes for imaging and diagnostics.

• Chemical Biology: Facilitates metabolic labeling studies and orthogonal conjugation.

Storage and Handling

• Storage: Store at –20 °C in a sealed container, protected from moisture and light.

• Handling: Dissolve freshly in aqueous buffer; avoid repeated freeze–thaw cycles.

This product integrates a bioorthogonal alkyne with amino acid chemistry, specifically providing a versatile tool for protein labeling, metabolic incorporation, and chemical biology research.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.