DSS Crosslinker
This product is a homobifunctional, non-cleavable crosslinker containing two NHS esters that react efficiently with primary amines. Its suberate spacer provides moderate length and stability, making DSS especially useful for protein crosslinking, structural biology, and biochemical conjugation applications.
Key Features and Benefits:
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Dual NHS Esters: React rapidly with primary amines under mild conditions.
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Non-cleavable Design: Provides stable, irreversible crosslinks.
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Suberate Spacer: Offers moderate chain length for structural flexibility.
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High Purity: Ensures consistent results in sensitive workflows.
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Broad Utility: Compatible with proteins, peptides, and synthetic scaffolds.
Applications:
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Protein Crosslinking: Stabilizes protein–protein interactions for analysis.
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Structural Biology: Maps biomolecular complexes through covalent linkage.
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Bioconjugation: Couples amine-rich biomolecules for assay development.
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Probe Development: Creates stable, non-cleavable conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a dry, moisture-free container.
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Handling: Prepare fresh solutions in anhydrous solvents (e.g., DMSO); avoid hydrolysis of NHS esters.
This product provides stable amine-to-amine coupling with a non-cleavable spacer, making it an especially reliable tool for crosslinking studies, structural biology, and bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
