TCO-PEG3-TCO
This product is a homobifunctional PEG linker containing two trans-cyclooctene (TCO) groups connected by a PEG3 spacer. It enables rapid tetrazine click chemistry, providing a compact, soluble, and especially reactive crosslinker for bioconjugation and probe development.
Key Features and Benefits
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Dual TCO Groups: React rapidly with tetrazines via IEDDA click chemistry.
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PEG3 Spacer: Improves solubility while maintaining compact spacing.
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Homobifunctional Design: Enables symmetric crosslinking with tetrazine-modified molecules.
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Bioorthogonal Reactivity: Performs in complex biological environments.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Crosslinks tetrazine-modified proteins, peptides, or small molecules.
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Probe Development: Builds dual-reactive probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal reactivity.
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Material Science: Functionalizes polymers, nanoparticles, and surfaces with click handles.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates dual TCO click groups with a PEG3 spacer, offering a compact and efficient linker specifically for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
