Acid-PEG5-mono-methyl ester
This product is a heterobifunctional PEG linker featuring a free carboxylic acid, a five-unit PEG spacer, and a protected methyl ester. The acid group couples efficiently with amines to form stable amide bonds, while the methyl ester provides a protected site for later deprotection or further derivatization. The PEG5 chain specifically offers solubility and flexibility, making this reagent useful for stepwise conjugation, PEGylation, and bioconjugation.
Key Features and Benefits
-
Carboxylic Acid Group: Couples readily with primary amines for amide formation.
-
Methyl Ester: Serves as a protected carboxyl for controlled sequential chemistry.
-
PEG5 Spacer: Improves solubility and reduces steric hindrance.
-
Stepwise Conjugation: Enables orthogonal functionalization strategies.
-
High Purity: Produced to ≥95% purity for reproducibility.
Applications
-
Bioconjugation: Links biomolecules via acid/amine coupling while retaining a protected group.
-
Peptide Synthesis: Incorporates PEG spacers with controlled protection.
-
Drug Delivery: Serves as a modular PEGylated linker for therapeutics.
-
Organic Synthesis: Provides a building block for multifunctional linkers.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, desiccated container.
-
Handling: Deprotect the methyl ester under standard conditions when required.
This product combines free and protected carboxyl functionality in a PEG5 scaffold, specifically offering flexibility for controlled synthesis and advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
