t-Boc-N-Amido-PEG6-CH2COOH
t-Boc-N-Amido-PEG6-CH2COOH is a high-purity heterobifunctional PEG linker with a t-Boc–protected amine for orthogonal conjugation and a terminal carboxylic acid specifically for versatile coupling. The PEG6 spacer improves aqueous solubility, enhances flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The acid-labile t-Boc group allows controlled deprotection for stepwise functionalization, making this reagent especially suitable for precision linker design in drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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t-Boc–Protected Amine: Enables orthogonal, controlled deprotection for sequential conjugation.
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Carboxylic Acid Group: Couples to primary amines via carbodiimide or other activation chemistries.
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PEG6 Spacer: Improves solubility, flexibility, and accessibility of reactive sites.
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Heterobifunctional Design: Supports multi-step bioconjugation strategies.
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High Purity: Supplied at >95% purity for reproducible, high-yield results.
Applications
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Stepwise Bioconjugation: Sequentially couple amines and acids for multifunctional constructs.
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Protein and Peptide Modification: Introduce amine and acid handles for orthogonal labeling.
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Nanoparticle Functionalization: Add hydrophilic, reactive spacers to surfaces.
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Drug Delivery Systems: Design linkers for precise payload attachment and release.
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Diagnostic Probe Development: Build multifunctional probes for imaging and biosensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
t-Boc-N-Amido-PEG6-CH2COOH combines a protected amine with a reactive carboxylic acid in a hydrophilic PEG6 framework, offering orthogonal reactivity and espeically high solubility for precision bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
