Mal-NH-ethyl-SS-propionic acid
This product is a heterobifunctional linker with a maleimide, a cleavable disulfide, and a terminal carboxyl group. The maleimide reacts selectively with thiols, while the disulfide allows reductive cleavage for controlled release. The carboxyl couples efficiently with amines or activated esters, making this reagent especially ideal for bioconjugation and drug delivery.
Key Features and Benefits
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Maleimide Group: Reacts selectively with thiols to form stable thioether bonds.
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Disulfide Bond: Provides reductive cleavage for controlled release.
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Carboxylic Acid Group: Couples with amines or NHS esters for amide formation.
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Compact Structure: Minimizes steric hindrance while maintaining functionality.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Drug Delivery: Creates cleavable linkers for controlled therapeutic release.
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Bioconjugation: Links thiol- and amine-modified biomolecules.
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ADC Development: Serves as a cleavable spacer in antibody–drug conjugates.
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Probe Design: Builds reducible, multifunctional imaging probes.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product specifically integrates thiol reactivity, reductive cleavability, and amine-coupling functionality in a compact scaffold for controlled conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
