Acid-PEG6-SS-PEG6-acid
This product is a bifunctional PEG linker containing terminal carboxyl groups and a central disulfide bond. It specifically enables amide coupling and redox-sensitive cleavage, providing solubility, flexibility, and cleavable functionality for bioconjugation and drug delivery.
Key Features and Benefits
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Carboxyl Groups: Couple efficiently with amines to form stable amide bonds.
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Disulfide Bond: Provides reversible linkage, cleavable under reducing conditions.
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PEG6 Spacers: Enhance solubility and biocompatibility with medium-length flexibility.
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Redox Sensitivity: Enables controlled release in reducing intracellular environments.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links biomolecules with cleavable disulfide chemistry.
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Drug Delivery: Provides redox-sensitive PEG scaffolds for controlled release.
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Probe Development: Builds multifunctional probes with cleavable handles.
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Material Science: Functionalizes polymers and nanoparticles with responsive linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature reduction or oxidation.
This product integrates dual carboxyl groups with a disulfide linkage in PEG6 scaffolds, specifically offering solubility, flexibility, and cleavable functionality.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
