Acid-PEG4-SS-PEG4-acid
Acid-PEG4-SS-PEG4-acid is a high-purity bifunctional PEG linker with two terminal carboxylic acids specifically for amide bond formation, connected by a PEG4–disulfide–PEG4 spacer. The cleavable disulfide bond especially enables controlled release under mild reducing conditions, while the PEG segments improve solubility, flexibility, and reduce steric hindrance, supporting efficient and reversible bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Dual Carboxylic Acids – Enable symmetric or dual-site amide coupling with primary amines
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Cleavable Disulfide Bond – Allows controlled linker cleavage under reducing conditions (e.g., DTT, TCEP, intracellular glutathione)
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PEG4 Spacers – Enhance aqueous solubility, flexibility, and accessibility of reactive groups
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Reversible Conjugation – Ideal for applications requiring release of conjugated payloads
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High Purity – Supplied at >95% purity for consistent, reproducible performance
Applications
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Reversible protein, peptide, and antibody conjugation
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Controlled-release drug delivery systems
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Antibody–drug conjugate (ADC) development
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Crosslinking studies with cleavable linkers
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Biodegradable polymer and material synthesis
Storage and Handling
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Store at –20 °C, dry, and protected from light
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Use anhydrous solvents such as DMSO or DMF for dissolution
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Avoid prolonged exposure to moisture and strong oxidizers to maintain disulfide integrity
This product is a cleavable bifunctional PEG linker with two carboxylic acids for amide coupling and a central disulfide bond for controlled release, separated by PEG4 segments specifically for enhanced solubility and flexibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
