DBCO-PEG9-NH-Boc
This product is a dibenzocyclooctyne (DBCO) derivative with a PEG9 spacer and a protected amine group (Boc). It specifically enables copper-free click chemistry with azides and provides an orthogonal amine handle for downstream functionalization.
Key Features and Benefits
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DBCO Group: Supports strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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PEG9 Spacer: Improves solubility and reduces steric hindrance.
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Boc-Protected Amine: Allows orthogonal deprotection for selective conjugation.
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Dual Functionality: Combines click chemistry with protected amine reactivity.
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High Purity: Ensures reproducible results in demanding conjugation workflows.
Applications
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Bioconjugation: Couples azide-labeled biomolecules via copper-free click chemistry.
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Probe Development: Builds multifunctional probes with amine and DBCO handles.
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Drug Delivery: Provides PEGylated scaffolds with bioorthogonal click reactivity.
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Material Science: Functionalizes polymers and nanoparticles with dual chemistry.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to prevent hydrolysis.
This product integrates copper-free click reactivity with a Boc-protected amine in a PEG9 scaffold, making it an especially versatile tool for advanced bioconjugation and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
