Fmoc-PEG1-NHS ester
This product is a compact heterobifunctional PEG linker containing an Fmoc-protected amine, a single ethylene glycol unit, and an NHS ester. The Fmoc group provides orthogonal protection for stepwise synthesis, while the NHS ester couples efficiently with primary amines to form stable amide bonds. Its short PEG1 spacer offers minimal added length while improving solubility, making it highly suitable for controlled peptide synthesis and bioconjugation.
Key Features and Benefits
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Fmoc-Protected Amine: Stable during synthesis, removable with mild base.
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NHS Ester: Couples readily with amines for efficient amide bond formation.
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PEG1 Spacer: Provides compact hydrophilicity and reduced steric hindrance.
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Orthogonal Reactivity: Supports sequential conjugation strategies in synthesis.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Peptide Synthesis: Incorporates PEG units in SPPS workflows.
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Bioconjugation: Links proteins, peptides, or probes via amine/acid chemistry.
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Drug Delivery: Functions as a modular PEG linker in therapeutic design.
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Probe Development: Builds multifunctional PEGylated probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect Fmoc under standard SPPS conditions; prepare fresh solutions before use.
This product integrates Fmoc protection with amine-reactive NHS chemistry in a compact PEG1 scaffold, providing an especially versatile tool for peptide synthesis and controlled conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
