Propargyl-PEG1-NHS ester
This product is a heterobifunctional linker featuring a terminal propargyl (alkyne) for click chemistry and an NHS ester for rapid amine conjugation. The short PEG1 spacer provides compact flexibility and hydrophilicity, making it especially ideal for probe design, multifunctional bioconjugation, and drug delivery.
Key Features and Benefits:
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG1 Spacer: Offers solubility and compact steric spacing.
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Dual Reactivity: Supports orthogonal conjugation strategies.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Links amine- and azide-containing biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides compact PEGylated scaffolds with reactive groups.
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Synthetic Chemistry: Useful intermediate for dual-functional linker design.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); prepare fresh solutions to minimize NHS ester hydrolysis.
This product combines click-ready alkyne functionality with efficient amine reactivity in a PEG1 scaffold, specifically offering solubility and compact design for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
