endo-BCN-PEG1-NHS carbonate
This product is a heterobifunctional linker featuring an endo-bicyclononyne (BCN) group for copper-free SPAAC ligation and an NHS carbonate for efficient amine coupling. The PEG1 spacer specifically improves solubility while maintaining compact design, making it ideal for bioorthogonal labeling, probe development, and therapeutic research.
Key Features and Benefits:
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Endo-BCN Group: Enables rapid, copper-free click chemistry with azides.
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NHS Carbonate: Couples efficiently with primary and secondary amines.
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PEG1 Spacer: Enhances solubility with minimal steric bulk.
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Dual Reactivity: Supports orthogonal click and amine conjugation.
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High Purity: Provides reproducibility in bioconjugation workflows.
Applications:
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Bioorthogonal Labeling: Rapidly links azide-modified biomolecules.
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Bioconjugation: Combines SPAAC reactivity with amine coupling.
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Probe Development: Builds stable, multifunctional imaging or diagnostic probes.
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Drug Delivery: Useful for targeted conjugation with enhanced solubility.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged light exposure to preserve BCN activity.
This product integrates copper-free BCN click chemistry with amine-reactive NHS carbonate, making it a compact and versatile tool specifically for bioorthogonal conjugation and advanced probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
