MC(C2)-Val-Cit-PAB-OH
This product is a cleavable linker composed of maleimidocaproyl (MC, with a C2 extension), the Val–Cit dipeptide, and a PAB self-immolative spacer. The MC enables thiol conjugation, Val–Cit allows cathepsin B cleavage, and PAB specifically ensures efficient payload release for ADC design.
Key Features and Benefits:
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Maleimidocaproyl (C2 Extension): Provides thiol reactivity for stable cysteine conjugation.
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Val–Cit Dipeptide: Cleavable by cathepsin B and related proteases for selective release.
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PAB Spacer: Self-immolative group promotes effective drug liberation after cleavage.
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Hydroxyl Terminus: Versatile handle for further modification or payload extension.
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High Purity: Ensures reproducibility in ADC and conjugation workflows.
Applications:
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ADC Development: Enables stable thiol linkage and protease-triggered payload release.
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Drug Delivery: Supports tumor-targeted release in intracellular environments.
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Bioconjugation: Combines cysteine coupling with controlled enzymatic cleavage.
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Synthetic Chemistry: Intermediate for building multifunctional linker–drug scaffolds.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve maleimide reactivity; avoid prolonged exposure to light and moisture.
This product integrates thiol reactivity, protease-cleavable functionality, and a self-immolative spacer, making it a key linker specifically in ADC development and targeted bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
