DBCO-Sulfo-PEG4-Maleimide
This product is a heterobifunctional linker combining a DBCO group for copper-free SPAAC click chemistry and a maleimide group for selective thiol conjugation. The sulfonated PEG4 spacer enhances solubility, flexibility, and spacing, making it especially effective for bioconjugation, ADC design, and probe development.
Key Features and Benefits:
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DBCO Group: Enables ultrafast, copper-free click reactions with azides.
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Maleimide Group: Selectively reacts with thiols for stable cysteine conjugation.
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Sulfo-PEG4 Spacer: Improves hydrophilicity, solubility, and steric accessibility.
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Dual Reactivity: Supports orthogonal conjugation strategies.
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High Purity: Provides reproducibility in advanced workflows.
Applications:
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Bioconjugation: Couples azide- and thiol-containing biomolecules with high selectivity.
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ADC Development: Serves as a linker for antibody–drug conjugates.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Supports targeted conjugation for therapeutic applications.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to moisture to preserve maleimide activity.
This product integrates copper-free click chemistry with thiol-specific conjugation in a sulfonated PEG scaffold, making it a especially versatile tool for targeted bioconjugation, probe design, and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
