TCO-PEG2-DBCO
This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) group, a short PEG2 spacer, and a dibenzocyclooctyne (DBCO) moiety. The TCO undergoes ultrafast, copper-free inverse electron-demand Diels–Alder (IEDDA) ligation with tetrazines, while the DBCO reacts rapidly with azides via SPAAC click chemistry. The PEG2 spacer specifically provides solubility and minimal flexibility, making this a compact, dual-reactive linker for bioorthogonal conjugation.
Key Features and Benefits
-
TCO Group: Supports rapid, copper-free IEDDA ligation with tetrazines.
-
DBCO Group: Performs efficient SPAAC click chemistry with azides.
-
PEG2 Spacer: Adds hydrophilicity with minimal length.
-
Dual Bioorthogonal Handles: Enables orthogonal conjugation strategies in one reagent.
-
High Purity: Produced to ≥95% purity for reproducibility.
Applications
-
Bioconjugation: Links tetrazine- and azide-modified biomolecules.
-
Protein and Antibody Labeling: Provides dual handles for multifunctional modification.
-
Probe Development: Builds dual-reactive probes for imaging and diagnostics.
-
Drug Delivery: Serves as a modular linker in multifunctional therapeutic systems.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
-
Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines two orthogonal click chemistries in a compact PEG2 scaffold, specifically offering powerful versatility for chemical biology and conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
