TCO-PEG5-amine
This product is a bifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG5 spacer, and a terminal primary amine. It enables rapid tetrazine click chemistry and provides an amine handle for amide coupling, making it especially versatile for bioconjugation.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) click chemistry.
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Primary Amine: Couples with carboxyls, NHS esters, or activated linkers.
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PEG5 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines TCO click chemistry with amine conjugation.
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High Purity: Ensures reliable results in sensitive applications.
Applications
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Bioconjugation: Links TCO-modified and amine-reactive biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal conjugation handles.
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Material Science: Functionalizes polymers and nanoparticles with dual reactivity.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates TCO click reactivity with amine coupling chemistry in a PEG5 scaffold, specifically offering a flexible and soluble linker for bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
