TCO-PEG7-maleimide
This product is a bifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG7 spacer, and a maleimide group. It enables rapid tetrazine click chemistry and selective thiol conjugation, specifically offering dual orthogonal reactivity for bioconjugation and probe development.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) chemistry.
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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PEG7 Spacer: Enhances solubility and provides flexible spacing.
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Dual Reactivity: Combines click and thiol chemistries in a single linker.
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High Purity: Ensures reproducible performance in demanding workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with tetrazine-modified partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides scaffolds with orthogonal conjugation handles.
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Material Science: Functionalizes polymers and nanoparticles with dual chemistry.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product integrates TCO–tetrazine click reactivity with maleimide–thiol coupling in a PEG7 scaffold, making it an especially powerful linker for advanced bioconjugation and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
