TCO-PEG4-acid
This product is a PEG linker containing a trans-cyclooctene (TCO) group, a PEG4 spacer, and a terminal carboxylic acid. It enables rapid tetrazine click chemistry and amide coupling, specifically providing solubility and orthogonal functionality in a compact scaffold.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via IEDDA click chemistry.
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Carboxylic Acid: Couples efficiently with primary amines to form stable amide bonds.
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PEG4 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with carboxyl conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links tetrazine-modified molecules with amine-containing partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with click and carboxyl handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates TCO click reactivity with carboxyl functionality in a PEG4 scaffold, specifically offering solubility and dual conjugation capability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
