TCO-PEG2-acid
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a terminal carboxylic acid for amide coupling. The PEG2 spacer improves solubility and compact flexibility, making it especially effective for bioorthogonal labeling, probe development, and drug delivery.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free IEDDA ligation with tetrazines.
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Carboxylic Acid: Couples efficiently with amines for stable amide bonds.
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PEG2 Spacer: Provides solubility and reduced steric hindrance.
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Dual Reactivity: Combines bioorthogonal and amide conjugation.
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High Purity: Ensures reliable, reproducible results.
Applications:
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Bioorthogonal Labeling: Allows ultrafast tetrazine ligation in vitro and in vivo.
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Probe Development: Builds TCO-functionalized probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds for targeted therapeutic conjugates.
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Bioconjugation: Supports multifunctional and orthogonal linker strategies.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect TCO from prolonged light exposure.
This product integrates bioorthogonal TCO reactivity with amine-coupling acid chemistry in a PEG2 scaffold, specifically making it a compact and versatile tool for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
