N,N-Bis(PEG2-propargyl)-4-oxo-butanoic NHS ester
This product is a multifunctional PEG linker with two terminal propargyl (alkyne) groups for click chemistry and an NHS ester for amine coupling. The PEG2 spacers provide solubility and flexibility, making it especially effective for bioconjugation, probe development, and multifunctional scaffold design.
Key Features and Benefits:
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Dual Propargyl Groups: Enable CuAAC and SPAAC click chemistry with azides.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG2 Spacers: Improve solubility, hydrophilicity, and steric accessibility.
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Multifunctional Design: Supports orthogonal, stepwise conjugation.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Combines amine reactivity with click-ready handles.
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Drug Delivery: Enables multifunctional payload attachment for controlled release.
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Probe Development: Builds dual-functional probes for imaging or diagnostics.
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Synthetic Chemistry: Serves as an intermediate for advanced scaffold construction.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of NHS ester.
This product integrates dual alkyne groups with amine-reactive NHS chemistry, providing versatile functionality specifically for probe design, ADC development, and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
