Mal-PEG4-t-Butyl ester
This product is a heterobifunctional linker with a maleimide group, a PEG4 spacer, and a protected t-butyl ester. The maleimide reacts selectively with thiols to form stable thioether bonds, while the t-butyl ester can be deprotected under mild acidic conditions to yield a carboxylic acid for further conjugation. The PEG4 spacer enhances solubility and flexibility, making this reagent especially valuable for stepwise conjugation in bioconjugation and drug delivery workflows.
Key Features and Benefits
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Maleimide Group: Enables efficient, selective conjugation with thiols.
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t-Butyl Ester: Protects the carboxyl until controlled deprotection is desired.
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PEG4 Spacer: Improves aqueous solubility and reduces steric hindrance.
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Stepwise Conjugation: Supports orthogonal functionalization strategies.
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High Purity: Produced to ≥95% purity for reproducible performance.
Applications
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Bioconjugation: Links thiol- and amine-functionalized biomolecules.
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Drug Delivery: Serves as a protected intermediate for PEGylated therapeutics.
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Probe Development: Builds multifunctional imaging and diagnostic probes.
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Synthetic Chemistry: Useful in designing controlled linker systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect t-butyl ester under mild acidic conditions when required; prepare fresh solutions before use.
This product combines thiol reactivity with a protected acid terminus on a flexible PEG4 scaffold, specifically providing a versatile tool for controlled conjugation and drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
