Fmoc-Val-Cit-PAB (CAS: 159858-22-7) is a cleavable linker used in antibody-drug conjugates (ADCs) to deliver drugs directly to target cells. It combines an Fmoc protective group, a Val-Cit peptide cleaved by lysosomal enzymes Cathepsin B, and a PAB spacer for efficient drug release.
Key Features:
- Fmoc Group: Protects during synthesis, removed in basic conditions.
- Val-Cit Peptide: Cleaved by cathepsin B for targeted drug release.
- PAB Spacer: Self-immolative, ensures complete drug release.
- High Purity: 98% or higher.
- Storage Stability: Store at -20°C in inert gas.
Applications:
- Antibody-Drug Conjugates (ADCs): Releases drugs selectively in target cells.
- Targeted Therapeutics: Allows precise drug delivery with minimal off-target effects.
- Cancer Research: Key in developing targeted treatments.
This linker is essential for creating ADCs that deliver active drugs specifically to diseased cells, boosting therapeutic effectiveness and reducing side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
