TCO-PEG1-Val-Cit-PAB-OH
This is a high-purity cleavable linker with a TCO group for rapid, catalyst-free tetrazine ligation. A short PEG1 spacer improves solubility and reduces steric hindrance. The Val-Cit-PAB unit enables protease-triggered payload release via self-immolation. It is ideal for antibody–drug conjugates and targeted delivery systems.
Key Features and Benefits
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TCO Group: Enables rapid, copper-free click reaction with tetrazines under mild conditions.
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Val-Cit-PAB Linker: Cleavable by proteases for controlled payload release.
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PEG1 Spacer: Improves solubility and reduces steric hindrance for efficient conjugation.
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Self-Immolative Design: Ensures clean release of the attached drug or probe.
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High Purity: Supplied at >95% purity for reliable performance.
Applications
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Antibody–drug conjugate (ADC) development.
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Targeted drug delivery systems.
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Prodrug and bioresponsive probe design.
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Pre-targeting and in vivo imaging strategies.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents; avoid prolonged exposure to moisture or heat to preserve reactivity.
This product combines fast TCO-tetrazine click reactivity with an enzyme-cleavable Val-Cit-PAB unit and a hydrophilic PEG1 spacer, enabling precise and controlled drug or probe release specifically in targeted delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
