Lipoamide-PEG-Mal is a lipoic acid PEG derivative used for surface modification of metal particles/films, the PEG chain has good water solubility, and maleimide can react with cysteine or thiol molecules to form thioether bond. Maleimides are reactive with thiols and form thioester bonds at pH 6.5 to 7.5.
Lipoamide-PEG-Mal is a multifunctional PEG polymer that is widely used in the field of pharmaceutical research and development. This polymer is composed of three distinct functional groups: lipoamide, polyethylene glycol (PEG), and maleimide.
The lipoamide group, derived from lipoic acid, is a thiol-containing molecule that allows for the covalent attachment of the polymer to various surfaces, such as nanoparticles and proteins. The PEG chain, on the other hand, provides hydrophilicity and steric stability to the polymer, preventing protein aggregation and improving its circulation time in vivo. The maleimide functional group is highly reactive and can react with thiol groups to form a stable thioether bond, making Lipoamide-PEG-Mal a versatile tool for the conjugation of therapeutic molecules.
Lipoamide-PEG-Mal
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP13301 | Lipoamide-PEG-Mal, MW 1K | Pricing | |
| AP13316 | Lipoamide-PEG-Mal, MW 2K | Pricing | |
| AP13333 | Lipoamide-PEG-Mal, MW 3.4K | Pricing | |
| AP13349 | Lipoamide-PEG-Mal, MW 5K | Pricing |
