DSPE-PEG-Maleimide (DSPE-PEG-Mal) is a phospholipid-PEG derivative. It improves drug stability and extends circulation time. The maleimide group binds easily with thiol-containing molecules, enabling precise bioconjugation. Commonly used in targeted therapies, it also plays a key role in nanotechnology and biomedical research.
DSPE-PEG-Maleimide
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP14947 | DSPE-PEG-Maleimide, MW 1K | Pricing | |
| AP13303 | DSPE-PEG-Maleimide, MW 2K | Pricing | |
| AP13327 | DSPE-PEG-Maleimide, MW 3.4K | Pricing | |
| AP13331 | DSPE-PEG-Maleimide, MW 5K | Pricing |
DSPE-PEG-Maleimide (DSPE-PEG-Mal) is a versatile phospholipid-PEG derivative used in drug delivery, nanotechnology, and medical research. It consists of DSPE, which integrates into lipid bilayers, and a PEG chain ending in a reactive maleimide group.
Key Features:
- Structure: DSPE integrates with lipid bilayers, while the PEG provides solubility and stealth properties. The maleimide group reacts quickly with thiol groups, allowing for efficient bioconjugation.
- Applications:
- Drug Delivery: It boosts drug solubility and circulation time. The PEG prolongs the half-life and reduces non-specific binding, while the maleimide enables targeted delivery by attaching antibodies, peptides, or other ligands.
- Nanoparticle Functionalization: It is widely used to functionalize liposomes and lipid PEG nanoparticles by binding targeting molecules like antibodies, aptamers, and peptides.
- Bioconjugation: The maleimide reacts specifically with thiol-containing biomolecules, making it perfect for targeted therapies.
- Medical Research and Materials Science: It supports cell culture, ligand studies, polypeptide synthesis, and development of functional coatings.
- Benefits: DSPE-PEG-Mal enhances drug stability and extends circulation time. It also offers a reliable way to attach targeting molecules, improving therapeutic precision.
Summary:
DSPE-PEG-Maleimide (DSPE-PEG-Mal) improves drug delivery by increasing stability and extending circulation. It enables precise bioconjugation, making it ideal for targeted therapies and advanced applications in nanotechnology, medical research, and materials science.