Folate-PEG-Thiol

Folate-PEG-Thiol (FA-PEG-SH) is a linear heterobifunctional PEG derivative with folic acid at one end and a thiol (-SH) group at the other end, which reacts with maleimide A covalent thioether bond is formed. Folate can strongly bind to the folate receptor, a known cancer biomarker, and the polymer could be used to prepare drug nanocarriers for targeted cancer therapy. It is used in drug delivery and other biomedical applications. The folate molecule is a B vitamin that has been shown to play an important role in cell growth and development, while the PEG molecule is a biocompatible polymer used to increase the solubility of the folate molecule and the thiol group is used to attach the folate molecule to a target molecule.