DBCO-PEG-Silane is a linear heterobifunctional PEG reagent with a DBCO and a silane. It is a useful crosslinking or bioconjugation reagent with a PEG spacer.
DBCO (dibenzocycolctyne) PEG Silane derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts.