Azide-PEG-thiol contains two functional groups: an azide group (-N3) and a thiol group (-SH) attached to a PEG chain.
The azide group in Azide-PEG-thiol has a unique property of undergoing a click reaction with alkyne or cyclooctyne functional groups, allowing for the formation of stable triazole linkages. This click chemistry approach has been widely used in the development of various drug delivery systems, including nanocarriers and prodrugs, by enabling the conjugation of drugs to the PEG chain in a controlled and efficient manner.
The thiol group in Azide-PEG-thiol can also be utilized for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain through disulfide bond formation. The resulting conjugates exhibit enhanced stability, improved solubility, and prolonged circulation time in vivo, leading to improved therapeutic efficacy and reduced side effects.
Azide-PEG-thiol
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP14954 | Azide-PEG-thiol, MW 1K | Pricing | |
| AP14955 | Azide-PEG-thiol, MW 3.4K | Pricing | |
| AP14956 | Azide-PEG-thiol, MW 5K | Pricing | |
| AP14957 | Azide-PEG-thiol, MW 10K | Pricing |
