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Hydroxyl PEG Amine (HO-PEG-NH2) is a heterobifunctional PEG polymer. It has a hydroxyl group on one end and an amine group on the other. It works well as a crosslinker or spacer. The amine group reacts easily with NHS esters. The PEG chain provides water solubility and biocompatibility. It’s ideal for antibody-drug conjugates (ADCs), bioconjugation, and drug delivery.

Hydroxyl PEG Amine

Cat# Name Structure M.W. Purity Pricing
AP14507Hydroxyl PEG Amine, HCl Salt, MW 1K
Quick viewHydroxyl PEG Amine, HCl Salt, MW 1K
1000≥95% Pricing
AP14508Hydroxyl PEG Amine, HCl Salt, MW 2K
Quick viewHydroxyl PEG Amine, HCl Salt, MW 2K
2000≥95% Pricing
AP14502Hydroxyl PEG Amine, HCl Salt, MW 3.5K
Quick viewHydroxyl PEG Amine, HCl Salt, MW 3.5K
3500≥95% Pricing
AP14503Hydroxyl PEG Amine, HCl Salt, MW 5K
Quick viewHydroxyl PEG Amine, HCl Salt, MW 5K
5000≥95% Pricing
AP14504Hydroxyl PEG Amine, HCl Salt, MW 7.5K
Quick viewHydroxyl PEG Amine, HCl Salt, MW 7.5K
7500≥95% Pricing
AP14505Hydroxyl PEG Amine, HCl Salt, MW 10K
Quick viewHydroxyl PEG Amine, HCl Salt, MW 10K
10000≥95% Pricing
AP14506Hydroxyl PEG Amine, HCl Salt, MW 20K
Quick viewHydroxyl PEG Amine, HCl Salt, MW 20K
20000≥95% Pricing

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    Hydroxyl PEG Amine (HO-PEG-NH2) is a heterobifunctional PEG derivative with a hydroxyl group (-OH) at one end and an amine group (-NH2) at the other.

    Key Features:

    1. Structure: The combination of a hydroxyl and an amine group makes it great for use as a crosslinker or spacer between two different chemical entities.
    2. Reactivity: The amine group easily reacts with activated NHS esters to form stable amide bonds. Meanwhile, the hydroxyl group can be further modified for added functionality.
    3. PEG Moiety: The PEG chain provides water solubility, biocompatibility, and flexibility, which are key benefits in biological applications.
    4. Applications:
      • Crosslinking and Spacing: Perfect for use as a crosslinker or spacer in complex chemical reactions.
      • Antibody Drug Conjugates (ADCs): Ideal for developing ADCs due to its functional versatility.
      • Bioconjugation: Great for attaching proteins, peptides, or drugs.
      • Drug Delivery: Improves the solubility and stability of therapeutic agents.
    5. Solubility: Its excellent solubility in water and organic solvents makes it versatile for various applications.

    Summary:

    Hydroxyl PEG Amine (HO-PEG-NH2) is a versatile crosslinker and spacer. It reacts efficiently with NHS esters, and its hydroxyl group can be further modified. The PEG structure offers biocompatibility and solubility, making it ideal for applications like ADC development, bioconjugation, and drug delivery.