MPEG-Orthopyridyl Disulfide (mPEG-OPSS), MW 5K is an ortho-pyridine disulfide or pyridine disulfide functional group, which can selectively react with free thiols, SH, sulfhydryl or sulfhydryl groups to form oxidative and reversible disulfides. Sulfur bond. Can be used to modify biomolecules or other materials by providing sulfhydryl groups. Polyethylene glycol can increase solubility and stability. It also inhibits the non-specific binding of charged molecules on the modified surface.