mPEG-Epoxide (mPEG-EPO) is a PEG derivative with a reactive epoxide group and a methoxy end. It is used in bioconjugation, surface modification, and cross-linking, providing enhanced solubility, stability, and biocompatibility for various biomedical and pharmaceutical applications.
m-PEG-Epoxide
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP14838 | mPEG-Epoxide, MW 2K | Pricing | |
| AP14839 | mPEG-Epoxide, MW 5K | Pricing |
mPEG-Epoxide (mPEG-EPO)
mPEG-Epoxide (mPEG-EPO) is a monofunctional polyethylene glycol (PEG) derivative featuring an epoxide group on one end and a methoxy group on the other. This compound is widely used in bioconjugation, surface modification, and polymer cross-linking due to its reactive epoxide group and the biocompatibility provided by the PEG chain.
Key Features and Applications:
- Reactive Epoxide Group: The epoxide end allows covalent bonding with nucleophiles such as amines, thiols, and hydroxyl groups, facilitating bioconjugation and surface coating.
- Methoxy-Terminated PEG: The methoxy group stabilizes the PEG chain, reduces immunogenicity, and enhances solubility in aqueous environments.
- Applications: Commonly used in PEGylation of proteins, nanoparticles, hydrogels, and other biomolecules, as well as in material science for modifying surfaces.
Usage and Handling:
- Reactivity: Epoxide groups are highly reactive under mild conditions, allowing for efficient and targeted coupling without damaging sensitive biomolecules.
- Storage: Store in a cool, dry place, away from moisture to maintain the reactivity of the epoxide group.
mPEG-Epoxide is valued in pharmaceutical and biomedical research for its versatility in modifying surfaces and creating biocompatible conjugates, enhancing the properties of drugs and biomaterials.