Epoxide-PEG-Epoxide (EPO-PEG-EPO) is a biocompatible PEG compound with reactive epoxide groups at both ends. It is commonly used in bioconjugation, cross-linking, and surface modification, enhancing solubility, stability, and functionality in biomedical and pharmaceutical applications.
Epoxide-PEG-Epoxide
Epoxide-PEG-Epoxide (EPO-PEG-EPO)
Epoxide-PEG-Epoxide (EPO-PEG-EPO) is a linear polyethylene glycol (PEG) derivative with reactive epoxide groups at both ends. This compound is widely used in bioconjugation, surface modification, and polymer cross-linking due to its water solubility, biocompatibility, and functional end groups.
Key Features and Applications:
- Bifunctional Epoxide Groups: The epoxide groups react with amines, thiols, and other nucleophiles, enabling covalent bonding to proteins, surfaces, and other molecules.
- Biocompatible PEG Spacer: The PEG segment provides flexibility, enhances solubility, and reduces non-specific binding, making it ideal for biomedical applications.
- Cross-Linking and Bioconjugation: Used for cross-linking hydrogels, modifying surfaces, and creating PEGylated proteins or nanoparticles.
Usage and Handling:
- Reactivity: The epoxide groups are reactive under mild conditions, making it suitable for gentle conjugation with sensitive biomolecules.
- Storage: Store in a cool, dry place away from moisture to preserve epoxide reactivity.
Epoxide-PEG-Epoxide is a versatile reagent in pharmaceutical, biomedical, and material science applications, offering efficient and stable linking of diverse molecules.