4arm PEG Succinimidyl Carboxymethyl Ester (4-Arm PEG-SCM) is a multi-arm PEG derivative with succinimidyl ester at the end of the four arms, which can be linked to the free amino group of the active drug , the aminoacetic acid bond produced by the coupling is more stable than the ester bond. The number of ethylene oxide units in the PEG chain may not be equal for all arms.