Thiol-PEG-Alcohol contains two functional groups, a thiol group (-SH) and an alcohol group (-OH), attached to the ends of a PEG chain.
The thiol group is known for its ability to react with other molecules through disulfide bond formation, while the alcohol group can be used for chemical modification or conjugation with other molecules via esterification or etherification reactions. These chemical properties make Thiol-PEG-Alcohol a versatile tool for drug delivery applications.
Thiol-PEG-Alcohol has been extensively used in the development of drug delivery systems, such as micelles, liposomes, and nanoparticles. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via disulfide bonds or esterification reactions. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.