Azido-PEG-CH2CO2-tBu

Azido-PEG-CH2CO2-tBu is a compound that belongs to the class of polyethylene glycol (PEG) derivatives. It is a functionalized molecule that contains an azide group, a tert-butyl ester group, and a carboxylic acid group. Azido-PEG-CH2CO2-tBu has gained significant attention in pharmaceutical research and development due to its ability to react with other molecules in a controlled manner, thus allowing for the synthesis of a wide range of drug conjugates. The azide group, for instance, can react with alkyne or cyclooctyne groups via click chemistry, while the carboxylic acid group can be used to attach a drug molecule through an amide bond. Furthermore, the tert-butyl ester group can be cleaved under mild acidic conditions, allowing for the release of the drug molecule in a controlled manner.