M-PEG-CH2COOH is a derivative of methoxy polyethylene glycol (M-PEG) with a carboxylic acid functional group (-COOH) and a methylene (-CH2-) linker. The carboxylic acid functional group is a versatile chemical moiety that can undergo various chemical reactions, such as esterification, amidation, and condensation, to modify the physical and chemical properties of M-PEG-CH2COOH. The methylene linker provides a flexible spacer between the carboxylic acid and the M-PEG chain, allowing for easy conjugation with other molecules.
In pharmaceutical research and development, M-PEG-CH2COOH is widely used as a drug delivery platform due to its biocompatibility, water solubility, and ability to extend the circulation time of drugs in the bloodstream. The carboxylic acid functional group enables the conjugation of targeting ligands, such as antibodies or peptides, to improve the specificity of drug delivery. Additionally, the methylene linker can be used to tune the hydrophobicity and steric hindrance of the drug conjugate to optimize its pharmacokinetic and pharmacodynamic properties.