Methoxy polyethylene glycol (M-PEG) acid is a synthetic polymer that contains functional groups such as methoxy and carboxylic acid. The methoxy group provides M-PEG acid with water solubility and biocompatibility, while the carboxylic acid group makes it amenable to chemical modifications and conjugation with other molecules.
In pharmaceutical research and development, M-PEG acid is widely used as a drug delivery system due to its ability to enhance the solubility and stability of poorly water-soluble drugs. It can also improve the pharmacokinetics and biodistribution of drugs by increasing their circulation time and reducing their clearance rate.
M-PEG acid can be conjugated with various targeting ligands such as antibodies or peptides, which enables selective delivery of drugs to specific cells or tissues, thus minimizing off-target effects and improving therapeutic efficacy. In addition, M-PEG acid can be used to prepare prodrugs, which are inactive compounds that can be converted into active drugs by enzymatic or chemical reactions in the body.