m-PEG Acid Chlorides feature a reactive acid chloride group that forms stable amide bonds with amines. The PEG spacer boosts solubility, stability, and biocompatibility. Researchers use them for drug delivery, bioconjugation, and surface coating applications.
m-PEG Acid Chloride
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP10149 | m-PEG2-CH2-acid chloride | Pricing | |
| AP10147 | m-PEG2-acid chloride | Pricing | |
| AP10150 | m-PEG3-CH2-acid chloride | Pricing | |
| AP10148 | m-PEG3-acid chloride | Pricing |
m-PEG Acid Chlorides are PEG-based compounds with a terminal acid chloride group, making them highly reactive for bioconjugation. The acid chloride forms stable amide bonds with amine-containing molecules, enabling the creation of drug delivery systems, antibody-drug conjugates (ADCs), and other bioconjugates. The PEG spacer improves water solubility, biocompatibility, and reduces immunogenicity.
Key Features:
- Reactive Acid Chloride Group: Forms strong amide bonds with amines for easy conjugation.
- Solubility and Stability: The PEG spacer enhances water solubility, reducing aggregation and increasing stability.
- Biocompatibility: Minimizes immunogenic responses, making it suitable for therapeutic applications.
Applications:
- Drug Delivery Systems: Used as a linker for prodrugs and ADCs, ensuring better drug stability and release.
- Bioconjugation: Attaches proteins, peptides, and imaging agents for diagnostics and therapeutics.
- Surface Modification: Coats surfaces like nanoparticles or polymers for biomedical applications.
How to Use:
- Storage: Keep at -20°C, away from light and moisture, for long-term stability.
- Solubility: Dissolves well in organic solvents like DCM and THF for chemical reactions.
Example Products:
- m-PEG3-acid chloride (CAS: 66722-87-0): Reacts with amines in the presence of activators like EDC or DCC to form stable amide bonds.
- m-PEG2-acid chloride: Works well in amide coupling reactions, boosting water solubility of final compounds.
These versatile linkers are essential tools in pharmaceutical, diagnostic, and biotechnological research, supporting advanced therapeutic and material development.